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The SD45 is a six-axle road switcher diesel-electric locomotive built by General Motors Electro-Motive Division between 1965–1971. It has an EMD 645E3 twenty-cylinder engine generating 3,600 hp (2,680 kW) on the same frame as the EMD SD38, EMD SD39, EMD SD40, and EMD SDP40. As of 2020, most SD45s have been retired, scrapped, or rebuilt to SD40-2 standards.